منابع مشابه
The role of Plasmodium falciparum food vacuole plasmepsins.
Plasmepsins (PMs) are thought to have an important function in hemoglobin degradation in the malarial parasite Plasmodium falciparum and have generated interest as antimalarial drug targets. Four paralogous plasmepsins reside in the food vacuole of P. falciparum. Targeted gene disruption by double crossover homologous recombination has been employed to study food vacuole plasmepsin function in ...
متن کاملPlasmodium falciparum falcilysin: an unprocessed food vacuole enzyme.
Five hundred million infections and nearly two million deaths each year are attributed to the protozoan Plasmodium falciparum, a causative agent of human malaria. With the increasing prevalence of drug resistant strains, there is an urgent need to identify new drug targets. Examination of the parasite’s unique metabolic pathways, such as hemoglobin degradation, provides candidates for chemother...
متن کاملInvestigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane proteins are known, the multidrug resistance protein 1 (PfMDR1) and Chloroquine Resistance Transporter (PfCRT). ...
متن کاملTrafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum
A family of aspartic proteases, the plasmepsins (PMs), plays a key role in the degradation of hemoglobin in the Plasmodium falciparum food vacuole. To study the trafficking of proPM II, we have modified the chromosomal PM II gene in P. falciparum to encode a proPM II-GFP chimera. By taking advantage of green fluorescent protein fluorescence in live parasites, the ultrastructural resolution of i...
متن کاملThe antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.
The marine natural product symplostatin 4 (Sym4) has been recognized as a potent antimalarial agent. However, its mode of action and, in particular, direct targets have to date remained elusive. We report a chemical synthesis of Sym4 and show that Sym4-treatment of P. falciparum-infected red blood cells (RBCs) results in the generation of a swollen food vacuole phenotype and a reduction of para...
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ژورنال
عنوان ژورنال: The Biological Bulletin
سال: 1947
ISSN: 0006-3185,1939-8697
DOI: 10.2307/1537967